Tetraploidy tolerance promotes cancer evolution
نویسندگان
چکیده
منابع مشابه
Tetraploidy in hydatidiform moles.
STUDY QUESTION How does tetraploidy develop in hydatidiform moles (HMs), and what is the frequency of the different origins? SUMMARY ANSWER Most molar pregnancies with tetraploid cells appear to be produced by somatic endoreduplications, while a minority originate from a tetraploid zygote. The frequency of zygotic tetraploidy was estimated to be 0.7%. WHAT IS KNOWN ALREADY The parental orig...
متن کاملTetraploidy Enhances Boron-Excess Tolerance in Carrizo Citrange (Citrus sinensis L. Osb. × Poncirus trifoliata L. Raf.)
UNLABELLED Tetraploidy modifies root anatomy which may lead to differentiated capacity to uptake and transport mineral elements. This work provides insights into physiological and molecular characters involved in boron (B) toxicity responses in diploid (2x) and tetraploid (4x) plants of Carrizo citrange (Citrus sinensis L. Osb. × Poncirus trifoliata L. Raf.), a widely used citrus rootstock. Wit...
متن کاملTetraploidy and tumor development
Tetraploid cells, which contain a doubled chromosomal content, are known to facilitate tumorigenesis [1]. Two specific characteristics of tetraploid cells play major roles in promoting neoplastic transformation. First, proliferating tetraploid cells are genomically unstable and accumulate both numerical and structural chromosomal abnormalities. Such chromosomal instability arises mainly due to ...
متن کاملHsp90 Promotes Kinase Evolution
Heat-shock protein 90 (Hsp90) promotes the maturation and stability of its client proteins, including many kinases. In doing so, Hsp90 may allow its clients to accumulate mutations as previously proposed by the capacitor hypothesis. If true, Hsp90 clients should show increased evolutionary rate compared with nonclients; however, other factors, such as gene expression and protein connectivity, m...
متن کاملTetraploidy in a liveborn infant.
We report a 3 month old boy with tetraploidy, found in peripheral blood and skin fibroblast cultures, with severely delayed growth and neurodevelopment, and with a cleft lip; these findings have not been described before. This report brings to seven the total number of liveborn infants with a 92,XXYY karyotype.
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2014
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3694